New versions (11.2, August 2024) of the IRAC MoA resources have been released and posted on the website. The changes include the following updates:

• Group 37: A new MoA Group which has been named “Vesicular acetylcholine transporter (VAChT) inhibitors”.
• Group 37: Oxazosulfyl has been moved from Group UN to the new Group 37.
• Group UNE: Sabadilla Extract has been classified as “Botanical essence including synthetic, extracts and unrefined oils with unknown or uncertain MoA”
• Group UNM: Polydimethylsiloxane (PDMS) has been classified as “Non-specific mechanical and physical disruptors”
• Group 35: Vadescana has been classified as “RNA Interference mediated target suppressor” in the MoA Classification under Appendix 6 as pending registration.
• Group UNM: Perlite has been classified as a “Non-specific mechanical and physical disruptor” in the MoA Classification under Appendix 6 as pending registration.

The updated resources, available for download from the IRAC website, are:

• The MoA Classification Scheme
• The MoA Poster (English edition) with the chemical structures
• The MoA Brochure
• The MoA website online search tool
• The MoA IRAC and RAC Global Resistance Management Apps